Using data from the UK Biobank, the GLAD Study and PROTECT, we performed the largest genome-wide meta-analyses (GWAS) of the nine depression symptom items, plus their sum score, on the Patient Health Questionnaire (PHQ-9) (GWAS equivalent N: 224,535–308,421). Assessing depression symptom specific genetic associations may better clarify this relationship. Lewis, View ORCID Profile Petroula Proitsi, AddNeuroMed, GERAD1 Consortium the Alzheimer’s Disease Neuroimaging Initiativeĭepression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence for their genetic relationship is mixed.
Eley, View ORCID Profile Gerome Breen, View ORCID Profile Alfredo Iacoangeli, Sulev Koks, View ORCID Profile Cathryn M. Davies, View ORCID Profile Christopher Hübel, View ORCID Profile Shannon Bristow, View ORCID Profile Sang Hyuck Lee, View ORCID Profile Henry Rogers, View ORCID Profile Charles Curtis, View ORCID Profile Gursharan Kalsi, View ORCID Profile Ryan Arathimos, View ORCID Profile Anne Corbett, View ORCID Profile Clive Ballard, View ORCID Profile Helen Brooker, View ORCID Profile Byron Creese, View ORCID Profile Dag Aarsland, Adam Hampshire, View ORCID Profile Latha Velayudhan, View ORCID Profile Thalia C. Davies, View ORCID Profile Jessica Mundy, View ORCID Profile Molly R.
Thorp, View ORCID Profile Brett Adey, View ORCID Profile Jodie Lord, Helena L. View ORCID Profile Lachlan Gilchrist, View ORCID Profile Thomas P.
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